CLA (Conjugated Linoleic Acid)

[ironmaster]

Any and all input, views and opinions on this supplement would be greatly appreciated, especially if you have experience with using this supplement. Thank you.


Semper Fi

[dopar66]

CLA didn't do anything for me, but I only took it for one bottle's worth. My wife has used CLA and supplements containing CLA for about 4 years now. She thinks it works for her. Her lean muscle mass is much better (her body fat is actually less % than mine....cough cough....) but that could also be attributed to her exercise and diet regimen. My $.02 is that it's similar to maybe L-carnitine, there are some substantiated things it does, but it's mostly hype.

Hope this helps.

God Bless.
Doug

[Chris Mangano]

Not sure what you are expecting CLA to do for you, but CLA's use as a fat burner pretty much sucks. However, it does seem to exhibit some effects as an anti-inflammatory.

"Cis-9,trans-11-CLA exerts anti-inflammatory effects in human bronchial epithelial cells and eosinophils: comparison to trans-10,cis-12-CLA and to linoleic acid.

Jaudszus A, Foerster M, Kroegel C, Wolf I, Jahreis G.

Institute of Nutrition, Friedrich Schiller University of Jena, Dornburger Str. 24, D-07743 Jena, Germany.

Interaction of eosinophils and bronchial epithelial cells plays a pivotal role in maintaining inflammatory airway disease. Since conjugated linoleic acids (CLA) are suggested to exert anti-inflammatory effects, one purpose of this study was to compare cis-9,trans-11-CLA and trans-10,cis-12-CLA with regard to their influence on the stimulus-induced activation of eosinophils. ECP (eosinophil cationic protein) released in co-culture of stimulated and CLA-treated eosinophils with stimulated bronchial epithelial cells (BEAS-2B) was measured and cis-9,trans-11-CLA was found to be most potent in inhibiting ECP formation. Further, expression of the activation markers CD69 and CD13 induced by various stimuli (TNF-alpha, IL-5, IL-3) was significantly reduced in the presence of cis-9,trans-11-CLA. Subsequently, various concentrations of cis-9,trans-11-CLA vs. linoleic acid (LA, cis-9,cis-12-octadecadienoic acid) were tested for the effect on proliferative response and release of the pro-inflammatory cytokine IL-8 in stimulated BEAS-2B. Addition of cis-9,trans-11-CLA attenuated cell growth and significantly reduced IL-8 production at mRNA and protein levels. In contrast, LA had a slight stimulating effect on proliferation and was less effective in reducing the cytokine release. It was demonstrated that the inhibitory effect of cis-9,trans-11-CLA on IL-8 production is mediated through activation of the nuclear receptor PPARgamma, since blocking the receptor with a selective antagonist (GW9662) restored the stimulus-induced enhancement in IL-8 mRNA expression and protein secretion. PPARgamma has previously been shown to be closely involved in the downregulation of inflammation during hyperresponsiveness related to pulmonary immune responses. Thus, targeting PPARgamma, cis-9,trans-11-CLA might be of therapeutic value in the focus of airway disease while ameliorating inflammatory processes by affecting epithelial and eosinophil functions."

[dopar66]

Chris, that is a high-quality post, my friend! Thanks.

God Bless.
Doug

[Chris Mangano]

Thanks.

I should add that if you want to take CLA for it's anti-inflammatory effects, I would highly reccomend Flameout from Biotest. I have used this stuff and felt pain free in my knees in a matter of days, and my knees are shot. It's highly concentrated fish oil combined with CLA and works wonders.

[ironmaster]

Thanks to you both for your input and time to reply. Strong and safe lifting to you both.

Semper Fi