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Post by joverfield on Sept 7, 2009 6:13:57 GMT -5
Does anyone know anything about the OTC supplement IsoOxygene that is marketed for pain relief? I noticed it as an ingredient in a product called Releve by MHP.
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Post by 3speed on Sept 7, 2009 9:10:19 GMT -5
Cox 2 enzymes are naturally produced molecules manufactured by the body as we age, usually in response to trauma. It is the Cox 2 enzyme that is thought to be a major cause of the suffering associated with tender, swollen, aching, inflexible joints. The trick is to block just enough production of Cox 2 enzymes without blocking the Cox 1 enzymes. If you block too much Cox 1 enzymes, you can wind up with gastric bleeding, and if you block too much Cox 2 enzymes, you block downstream production of prostaglandins which are important for cardiac health. Further info: www.pureprescriptions.com/pdfs/IsoOxygene-vs-drugs.pdfNote: There are much cheaper sources than MHP available if you are interested in this supplement. |
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Post by joverfield on Sept 7, 2009 14:03:48 GMT -5
Thanks for the info 3speed. I saw in the description of the product Releve that it was a Cox-2 selective NSAID, but didn't know how it compared to the old Cox-2's that were deemed somewhat unsafe. I was on Vioxx for a while until it was pulled, and I haven't found anything that works since that isn't a narcotic (which I always tell the hospital/doctor I won't take). Unless someone has some advice as to why not to, I may give this a go and see if it works.
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Post by 3speed on Sept 7, 2009 18:35:18 GMT -5
Vioxx was pulled from the market because it almost completely inhibited the COX 2 enzyme leading to concerns about heart attack and stroke due to long term usage. The COX 2 enzyme mediates the synthesis of prostaglandins responsible for pain and inflammation. This IsoOxygene appears to be somewhere between Celebrex and Vioxx in it's ability to inhibit the COX 2 enzyme.
Just in case this product does what it is claimed to do, I would strongly suggest talking to your doctor about it before you decide to "give it a try". There could be some serious long term considerations concerning cardiovascular health.
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Post by RichHutchison on Sept 8, 2009 9:17:34 GMT -5
Something interesting about NSAIDs, including Ibuprofin, which I have lived on through heavy training periods. Dr. Gabe Mirkin's Fitness and Health E-Zine NSAIDs Interfere with Proper Training www.drmirkin.com/public/ezine090609.html September 6, 2009 Ibuprofen and other NSAIDs (Non Steroidal Anti-Inflammatory Drugs), taken before or after exercise, interfere with the benefits of training for fitness and athletic competition because they delay healing of damaged muscles (British Journal of Sports Medicine, August 2009). You train for sports by taking a hard workout that damages muscles and makes them feel sore. You then take easy, less intense workouts for as long as it takes for the soreness to go away. Only then should you take intense workouts again. Swimmers take hard and easy workouts every day, but athletes in virtually all other sports allow at least 48 hours between intense workouts. Biopsies done the day after a hard workout show bleeding into the muscle fibers and disruption of the Z-bands that hold muscle fibers together. Injured muscles release healing prostaglandins that cause collagen to be laid down in muscle fibers to make them larger and stronger. They also cause pain. NSAIDs block the training effect by blocking healing prostaglandins, thus delaying recovery and collagen production. They prevent bones, muscles, tendon and ligaments from thickening and becoming stronger. Athletes taking NSAIDs during competition are at increased risk for bleeding into their kidneys, and for intestinal bacteria to enter their bloodstreams (Brain, Behavior and Immunity, November 2006). An estimated 60 percent of athletes competing in triathlons and other endurance events take NSAIDs because they think that it will block the pain of competition. NSAIDs have not been shown to block the pain and fatigue of competing in athletic events that require endurance. |
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Post by joverfield on Sept 8, 2009 15:11:38 GMT -5
Vioxx was pulled from the market because it almost completely inhibited the COX 2 enzyme leading to concerns about heart attack and stroke due to long term usage. The COX 2 enzyme mediates the synthesis of prostaglandins responsible for pain and inflammation. This IsoOxygene appears to be somewhere between Celebrex and Vioxx in it's ability to inhibit the COX 2 enzyme. Just in case this product does what it is claimed to do, I would strongly suggest talking to your doctor about it before you decide to "give it a try". There could be some serious long term considerations concerning cardiovascular health. Thanks for the information and advice. I was thinking about printing the info off of the internet and showing it to my pain specialist before purchase. After being in discussion on this forum, I am definitely going to do this. |
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Post by joverfield on Sept 8, 2009 15:16:10 GMT -5
Something interesting about NSAIDs, including Ibuprofin, which I have lived on through heavy training periods. Dr. Gabe Mirkin's Fitness and Health E-Zine NSAIDs Interfere with Proper Training www.drmirkin.com/public/ezine090609.html September 6, 2009 Ibuprofen and other NSAIDs (Non Steroidal Anti-Inflammatory Drugs), taken before or after exercise, interfere with the benefits of training for fitness and athletic competition because they delay healing of damaged muscles (British Journal of Sports Medicine, August 2009). You train for sports by taking a hard workout that damages muscles and makes them feel sore. You then take easy, less intense workouts for as long as it takes for the soreness to go away. Only then should you take intense workouts again. Swimmers take hard and easy workouts every day, but athletes in virtually all other sports allow at least 48 hours between intense workouts. Biopsies done the day after a hard workout show bleeding into the muscle fibers and disruption of the Z-bands that hold muscle fibers together. Injured muscles release healing prostaglandins that cause collagen to be laid down in muscle fibers to make them larger and stronger. They also cause pain. NSAIDs block the training effect by blocking healing prostaglandins, thus delaying recovery and collagen production. They prevent bones, muscles, tendon and ligaments from thickening and becoming stronger. Athletes taking NSAIDs during competition are at increased risk for bleeding into their kidneys, and for intestinal bacteria to enter their bloodstreams (Brain, Behavior and Immunity, November 2006). An estimated 60 percent of athletes competing in triathlons and other endurance events take NSAIDs because they think that it will block the pain of competition. NSAIDs have not been shown to block the pain and fatigue of competing in athletic events that require endurance. Rich, Thank you. I had actually found this article a while back, and have cut my use of NSAIDS dramatically. I still take some prescription naproxen when my neck gets too bad (just had a cervical facet radiofrequency neurotomy done, so it is a little more than normal right now), but for the most part I don't take near what I used to. I even discussed this with my physical therapist when I found it, and he said he only takes tylenol so he can stay away from nsaids for this reason. Hopefully this procedure worked, and in three weeks I won't need anything any more.  |
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